Lancet 353 (1999): 1763-4, 38. Zocor Side Effect 2 - Myopathy. Drug Side Effects. glucose levels as are seen in. This is why gaining a full understanding of the risks and the benefits of the medication are part of an essential conversation to have with a health care provider to determine whether Zocor is right for you. In the pre-marketing controlled clinical studies and their open extensions (2,423 patients with median duration of follow-up of approximately 18 months), 1.4% of patients were discontinued due to adverse reactions. South Med J 98 (2005): 827-9, 35. Simons LA "Simvastatin in severe primary hypercholesterolemia: efficacy, safety, and tolerability in 595 patients over 18 weeks. What are the important side effects of Zocor (simvastatin)? Joe Graedon-March 02, 2017-41 Comments “I was placed on statin medication in 2004. Federman DG, Hussain F, Walters AB "Fatal rhabdomyolysis caused by lipid-lowering therapy." Galatti L, Polimeni G, Salvo F, Romani M, Sessa A, Spina E "Short-term memory loss associated with rosuvastatin." J Am Geriatr Soc 54 (2006): 70-6, 47. Cholesterol occurs naturally in the body. Pedersen TR, Berg K, Cook TJ, Faergeman O, Haghfelt T, Kjekshus J, Miettinen T, Musliner TA, Olsson AG, Pyorala K, Thorgeirsso "Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the scandinavian simvastatin survival study." Newman TB, Hulley SB "Carcinogenicity of lipid-lowering drugs." High cholesterol can be a dangerous condition. Curr Opin Lipidol 16 (2005): 640-7, 29. In this trial, patients were carefully monitored and some interacting medicinal products were excluded. other cardiovascular diseases. Lancet 341 (1993): 114. There have been rare postmarketing reports of hepatic failure. Alvarez JM, Rawdanowiz TJ, Goldstein J "Rhadbdomyolysis after coronary artery bypass grafting in a patient receiving simvastatin." [Ref], Frequency not reported: Elevations in creatine kinase, myopathy, dermatomyositis, arthralgia, tendon rupture, Postmarketing reports: Muscle cramps, myalgia, rhabdomyolysis[Ref], This drug causes dose-related myopathy which, in rare cases maybe severe and sometimes take the form of rhabdomyolysis with or without renal failure secondary to myoglobinuria; rarely fatalities have occurred. Because the below reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Zocor (simvastatin) side effects list for healthcare professionals. Arora R, Liebo M, Maldonado F "Statin-induced myopathy: the two faces of Janus." Table 2: Adverse Reactions Reported Regardless of Causality by ≥2% of Patients Treated with Zocor and Greater than Placebo in 4S. In a 48-week, controlled study in adolescent boys and girls who were at least 1 year post-menarche, 10-17 years of age (43.4% female, 97.7% Caucasians, 1.7% Hispanics, 0.6% Multiracial) with heterozygous familial hypercholesterolemia (n=175), treated with placebo or Zocor (10-40 mg daily), the most common adverse reactions observed in both groups were upper respiratory infection, headache, abdominal pain, and nausea. Plosker GL, Mctavish D "Simvastatin - a reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia." Learn cholesterol basics, drug classes, and available drugs along... Do you know the different cholesterol levels and what they mean? Duits N, Bos FM "Depressive symptoms and cholesterol-lowering drugs." Side effects reported by some people include muscle pain and digestive problems. You are encouraged to report negative side effects of prescription drugs to the FDA. These side effects include nausea, dizziness, and vomiting. Bjerre LM, LeLorier J "Do statins cause cancer? Br J Rheumatol 32 (1993): 647-8, 11. Pharmacotherapy 25 (2005): 228-43, 28. Johnson JL, Loomis IB "A case of simvastatin-associated pancreatitis and review of statin-associated pancreatitis." (low-density lipoprotein), or the "bad" cholesterol, are lipoproteins that carry In rare cases, Zocor can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to … Mukhtar RY, Reckless JP "Statin-induced myositis: a commonly encountered or rare side effect?" J Thorac Cardiovasc Surg 116 (1998): 654-5, 32. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The more commonly reported adverse effects have included upper respiratory infection, headache, abdominal pain, constipation, and nausea. Phan T, Mcleod JG, Pollard JD, Peiris O, Rohan A, Halpern JP "Peripheral neuropathy associated with simvastatin." With therapy discontinuation or interruption, transaminase levels generally returned to pretreatment levels. Zetia, atorvastatin, Jardiance, simvastatin, Brilinta, fenofibrate, Lopid, Xarelto, rosuvastatin, Lipitor. In patients with coronary heart disease, diabetes, peripheral vascular disease, or history of stroke or other cerebrovascular disease, simvastatin is prescribed for reducing the risk of mortality by reducing death from coronary heart disease, reducing nonfatal myocardial infarction (heart attack) and stroke, and reducing the need for coronary and noncoronary revascularization procedures. Katznelson S "Immunosuppressive and antiproliferative effects of HMG-CoA reductase inhibitors." Although not all of these side effects may occur, if they do occur they may need medical attention. may worsen the narrowing of the blood vessels in the body, which puts you at a 41 Comments. Ann Pharmacother 36 (2002): 288-95, 24. Myoglobin can cause, Statins have been associated with Myopathy is defined as any abnormal condition or disease of the muscle tissues, commonly involving skeletal tissue. Medically reviewed by Drugs.com. This was attributable to the noncardiac fraction of CK. Discontinuation rates due to adverse reactions were 4.8% in patients treated with Zocor compared with 5.1% in patients treated with placebo. `` effect of warfarin and the risk of myopathy, including rhabdomyolysis is increased by concomitant of. Abnormalities in four patients taking statins to treat unfavorable cholesterol levels and reduce cholesterol by eating foods that High! Adverse event reports on statin-associated rhabdomyolysis. inhibitors on chronic allograft rejection., 32 levels returned... Is dose-related, Chinese patients with simvastatin resulted in a patient receiving simvastatin. have... During the first year and then notably decreased during the first year and notably. 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