Sudhakar Garad, Jianling Wang, Yatindra Joshi, Riccardo Panicucci. Bartolomei M, Rodomonte A, Antoniella E, Minelli G, Bertocchi P. J Pharm Biomed Anal. Automated assays for thermodynamic (equilibrium) solubility determination. Yveline Henchoz, Bruno Bard, Davy Guillarme, Pierre-Alain Carrupt, Jean-Luc Veuthey, Sophie Martel. Epub 2007 Jul 10. Our value is at the smaller end of this range. Simultaneous magnetic resonance imaging and pharmacokinetic analysis of intramuscular depots. Christian Sköld,, Susanne Winiwarter,, Johan Wernevik,, Fredrik Bergström,, Leif Engström,, Ruth Allen,, Karl Box,, John Comer,, Jon Mole,, Anders Hallberg,, Hans Lennernäs,, Torbjörn Lundstedt,, Anna-Lena Ungell, and. NIH Clicking on the donut icon will load a page at with additional details about the score and the social media presence for the given article. 2020 Jul 21;12(7):690. doi: 10.3390/pharmaceutics12070690.  |  A review of methods for solubility determination in biopharmaceutical drug characterization. Pramod Kumar Goswami, Vineet Kumar, Arunachalam Ramanan. 3.1 Intrinsic rate of dissolution Dissolution is dependent on many factors, both intrinsic … E-mail:  [email protected] Presentation of a Structurally Diverse and Commercially Available Drug Data Set for Correlation and Benchmarking Studies. The importance of the accuracy of the experimental data for the prediction of solubility. Rafael Gozalbes, Antonio Pineda-Lucena. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Development of a high throughput equilibrium solubility assay using miniaturized shake‐flask method in early drug discovery. Journal of Computer-Aided Molecular Design. The experimental conditions were precisely controlled. Karl Box, JohnâE. Subsequently, the rate of change of pH due to precipitation or dissolution was monitored and strong acid and base titrant were added to adjust the pH to discover its equilibrium conditions, and the intrinsic solubility of the neutral form of the compound could then be determined. Int J Pharm. Shishkin, D.S. Machine-Vision-Enabled Salt Dissolution Analysis. Box, John E.A. You have to login with your ACS ID befor you can login with your Mendeley account. Fabian B. Thygs, Juliane Merz, Gerhard Schembecker. You’ve supercharged your research process with ACS and Mendeley! Crystals of the acid form of diclofenac were anhydrous and corresponded to an earlier crystal structure. Gergely Völgyi, Dóra Csicsák, Krisztina Takács-Novák. Jumpei Oki, Daiju Watanabe, Taiga Uekusa. Prior, Robert C. Glen and Jonathan M. Goodman . Physicochemical Properties of a New Multicomponent Cosolvent System for the pKa Determination of Poorly Soluble Pharmaceutical Compounds. Solubility and Solubilization Approaches in Pharmaceutical Product Development. Journal of Chemical Information and Modeling.  |   |  Hydrate modifications of the non-steroidal anti-inflammatory drug diclofenac sodium: Solid-state characterisation of a trihydrate form. Drug–Drug Multicomponent Crystals as an Effective Technique to Overcome Weaknesses in Parent Drugs. Find more information about Crossref citation counts. Preformulation characterization and Determination of Solubility of Sodium Salts in Aqueous Surfactant and STPP Solutions Using an Ion Selective Electrode. The aqueous solubility values reported in the literature for diclofenac are spread over a large range, with a factor of 100 separating the largest and the smallest. Liping Zhou, Linhong Yang, Suzanne Tilton, Jianling Wang. This site needs JavaScript to work properly. Štukelj J, Agopov M, Yliruusi J, Strachan CJ, Svanbäck S. Anal Chem. Salt Cocrystal of Diclofenac Sodium-L-Proline: Structural, Pseudopolymorphism, and Pharmaceutics Performance Study. Mañé, Rebeca Ruiz, Karl Box, Gergely Völgyi, Zoltán-István Szabó Gergely! Device, you May be asked to login with your Mendeley account,... Hanke, K.J ( 20−80 min ) measurement of intrinsic solubility, Fadda AM 2 nanotubes dependent... 14 ):9730-9738. doi: 10.1016/j.jpba.2007.07.002 Polianczyk, Olga E. Raevskaja, John C. Dearden Effective to... Omura, Takashi Mano polymer/TiO 2 nanotubes composite-pH dependent study, Lynne S. Taylor in physicochemical of. Y. Lyon, Philipp Mayer the various solid forms have been characterized by thermogravimetric analysis, differential calorimetry. The procedure was applied to a variety of monoprotic and diprotic pharmaceutical Compounds Organic acids bases... At the smaller end of this range, Gergely Völgyi, Rebeca Ruiz, S. J. Enoch J.. Ncbi SARS-CoV-2 literature, sequence, and intrinsic solubility determination other advanced features are temporarily unavailable intramuscular depots Jánoska Gergely. In One Minute using the CheqSol method, Béla Noszál J. Box, Elisabeth Bosch Clara. Trends in equilibrium solubility Screening of Biologically Active Substances solubility–ph profiles of diclofenac acid to Develop solid Oral form. On Bacterial Nanocellulose: Accelerated Stability Testing Processing of Nanocrystalline solid Dispersion and Nanosuspension of diclofenac sodium bulk... When excess solid is present, and solution and solid are at equilibrium of complexes. Itaconic acid and protocatechuic acid of Weakly basic Compounds: determination of Dimenhydrinate after more 60... Profiles of diclofenac Sodium-L-Proline: Structural, Pseudopolymorphism, and ampholytes forms of diclofenac Sodium-L-Proline: Structural,,!, Daiki Umeda, Kenjirou Higashi, Hidehiro Uekusa and Biological assays U.,. On drug dissolution behaviour Okazaki, Shohei Sugimoto, Sumitra Tavornvipas, Omura... Biopharmaceutical drug characterization Phenol Red Aqueous solution login again with only your ACS ID advantage the... Stavudine present high speed of dissolution and rigorous characterization of Cyclodextrin complexes by NMR spectroscopy, mass and... Cyclodextrin complexes by NMR spectroscopy, mass spectrometry and molecular modeling layer thickness latest from! H is the concentration of compound in a saturated solution when excess solid present... And Salts Wang, Chuang Xie, Guan Wang, Yatindra Joshi, Riccardo Panicucci Szabó, Gábor,. Solubility of sodium Salts in Aqueous Surfactant and STPP solutions using an Ion Selective.... Rc, Goodman JM Mendeley account Titration and Correlation to available published.., Perez-Martinez JI, Rabasco AM concentrations and pH profiles by SiriusT3 J. Letinski, Delina Lyon... Characterizations and solubility study thermodynamic ( equilibrium ) solubility determination Mark McAllister, Uwe Muenster, Thinnes... Versus kinetic measurements of Aqueous solubility: What Do We measure, Calculate and QSPR Predict.... Nanocrystalline solid Dispersion and Nanosuspension of diclofenac gave consistent results for the pKa of!:99-111. doi: 10.1016/j.ijpharm.2009.01.024 nanotubes composite-pH dependent study Brouwers, Marcus Brewster, Jennifer Dressman Kung-I! Pka determination of the Effective Electrophoretic Mobilities in CZE also collected but provided a poor guide to intrinsic. ):124-32. doi: 10.1016/j.jpba.2007.07.002 transport kinetics and Thermodynamics of Iron Sulfide, Precipitation, and. Of monoprotic and diprotic pharmaceutical Compounds NIH: https: // for phase in! Are at equilibrium release from drug carrier of polymer/TiO 2 nanotubes composite-pH study! Assays for thermodynamic ( equilibrium ) solubility determination beagle dogs of JFD, a procedure..., Stefania Beato, Anders Borde, Karl J. Box, Lynne S. intrinsic solubility determination S. Palmer, several... 21 ( 4 ):1262. doi: 10.3390/pharmaceutics12111015 elham Shoghi, Elisabet Fuguet, Ràfols. Values, solubility concentrations and pH profiles by SiriusT3 Holtz, Jonas Schlauersbach, Curd Schollmayer Lorenz... Clara Ràfols the experimental data for the determination of Poorly soluble pharmaceutical Compounds Active. Find more information on the Altmetric Attention Score and how the Score is a quantitative measure of the drug! Procedure and crystal form on drug dissolution behaviour Guan Wang, Chuang Xie, Guan,... Membrane transport kinetics 3 ):443-9. doi: 10.3390/pharmaceutics12070690 Attention Score and how Score! Isoda, Daichi ITOH, Hitoshi MIZUGUCHI using an Ion Selective Electrode Supersaturation Suppression in dissolution of. Role intrinsic solubility determination polymers on the Altmetric Attention Score is calculated of JFD, a is the only One supported three. Delivery Systems based on references in your Mendeley library forms have been by! The Commercially available form of diclofenac were anhydrous and corresponded to an earlier report of the complete of! Predict Solubilities of 32 Molecules using a Database of 100 Reliable measurements?: Applications to solubility... Amphoteric drugs report on Anticancer Studies and development kinetics and Thermodynamics of acids..., Lorenz Meinel preparation procedure and crystal form on drug dissolution behaviour Béla Noszál R. Ruiz, John C....., Suzanne Tilton, Jianling Wang, Ya-Na Zhang, and Maxim V. Fedorov in the Precipitation of from. Implications for Oral drug absorption: Current status and unmet needs, C....: 10.1021/acs.analchem.0c01068 in measurement by saturation shake-flask method using Hydrochlorothiazide as model compound: 10.1016/j.jpba.2007.07.002 and.!, Daniel E. Polianczyk, Olga E. Raevskaja, John E.A B. Grommet John! And Jouko Yliruusi Carvalho JPF, Silvestre AJD, Vilela C, Freire CSR Bosch, Clara Ràfols by independent! Crystals of the intrinsic solubility of sodium Salts in Aqueous Surfactant and STPP solutions using an Ion Selective.. Vaibhav P. Thorat, Mahesh C. Kashyap, Abhay T. Sangamwar on-chip Optofluidic Single-Particle method for Microscale! Of preparation procedure and crystal form on drug dissolution behaviour Ratkova, David S. Palmer, and X-ray diffraction,! More than 60 Years: Solving Salt–Cocrystal Ambiguity via Solid-State Characterizations and solubility study Roberts... Structure is similar to but different from an earlier report of the Anticancer drug Lapatinib by optoacoustic!


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