Bempedoic acid for the treatment of dyslipidemia. Wang X, Zhang Y, Tan H, Wang P, Zha X, Chong W, Zhou L, Fang F. Cardiovasc Diabetol. Epub 2017 Sep 5. Ballantyne CM, Banach M, Mancini GBJ, Lepor NE, Hanselman JC, Zhao X, Leiter LA. 2020 Oct;76(4):376-388. doi: 10.1097/FJC.0000000000000887. COVID-19 is an emerging, rapidly evolving situation. eCollection 2020. Efficacy and safety of bempedoic acid for prevention of cardiovascular events and diabetes: a systematic review and meta-analysis. Bempedoic acid may be a reasonable adjunct for LDL-C reduction, though further evaluation of cardiovascular outcomes with bempedoic acid in this population is needed. 2020 Jul 1;5(10):1-12. doi: 10.1001/jamacardio.2020.2314. NLM Jellinger PS, Handelsman Y, Rosenblit PD, Bloomgarden ZT, Fonseca VA, Garber AJ, Grunberger G, Guerin CK, Bell DSH, Mechanick JI, Pessah-Pollack R, Wyne K, Smith D, Brinton EA, Fazio S, Davidson M. Endocr Pract. We performed a systematic review and meta‐analysis on efficacy and safety of BA compared with standard treatment in patients with hypercholesterolemia. 2020 Aug 12;19(1):128. doi: 10.1186/s12933-020-01101-9. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2017 Oct 3;70(14):1785-1822. doi: 10.1016/j.jacc.2017.07.745. Bempedoic acid may be a reasonable adjunct for LDL-C reduction, though further evaluation of cardiovascular outcomes with bempedoic acid in this population is needed.  |  Introduction: Bempedoic acid (ETC-1002) is a first-in-class lipid-lowering agent recently approved by the United States (US) Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for commercialization.  |  Barkas F, Milionis H, Kostapanos MS, Mikhailidis DP, Elisaf M, Liberopoulos E. Curr Med Res Opin. 2017 Apr;23(Suppl 2):1-87. doi: 10.4158/EP171764.APPGL. The introduction of proprotein convertase subtilisin/kexin type 9 (PCSK-9) inhibitors in 2015 was a promising addition to hypercholesterolemia therapies, but their cost and subcutaneous administration has limited their use, and therefore, new affordable and patient friendly treatment strategies are crucial to help reduce ASCVD risk. Atherosclerosis. Get the latest research from NIH: https://www.nih.gov/coronavirus. 2017 Nov 9;6(11):e006537. The purpose of this review is to summarize the major clinical studies evaluating bempedoic acid and describe its potential addition to currently approved lipid-lowering therapies. Online ahead of print. 2020 May;80(7):747-753. doi: 10.1007/s40265-020-01308-w. 2017 Focused Update of the 2016 ACC Expert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk: A Report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways. COVID-19 is an emerging, rapidly evolving situation. Clipboard, Search History, and several other advanced features are temporarily unavailable. Bempedoic acid is administered orally once a day, is quickly absorbed in the small intestine, and has a half-life ranging from 15 to 24 hours . However, many patients cannot tolerate statin therapy because of statin-associated muscle symptoms. By inhibiting ACLY, bempedoic acid induces LDL receptor upregulation and stimulates the uptake of LDL particles by the liver, which contributes to reduction of LDL-C concentration in the blood . Epub 2018 Jun 12. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Despite the widespread use of statins and ezetimibe to decrease low-density lipoprotein cholesterol (LDL-C) levels and associated atherosclerotic cardiovascular disease (ASCVD), many patients do not achieve adequate LDL-C lowering as per the recommended American College of Cardiology (ACC)/American Heart Association (AHA) and European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines and demonstrate residual cardiovascular risk. Bempedoic acid is a prodrug and requires activation by the enzyme very-long-chain acyl-CoA synthetase 1, which is present in the liver but absent in most peripheral tissues. Epub 2014 Nov 24. doi: 10.1161/JAHA.117.006537. Bempedoic acid (BA; ETC-1002) is a new agent that reduces cholesterol synthesis through inhibition of adenosine triphosphate citrate lyase, an enzyme upstream from 3-hydroxy-3-methylglutaryl-coenzyme A.In animal models, BA also influences fatty acid synthesis, but in humans, its role is limited primarily to lowering low-density lipoprotein cholesterol (LDL-C). 2015 Feb;31(2):221-8. doi: 10.1185/03007995.2014.982751. Clipboard, Search History, and several other advanced features are temporarily unavailable. Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study. Conclusions: The recent FDA approval of bempedoic acid offers an additional option for lowering LDL-C levels in patients with atherosclerotic cardiovascular disease or heterozygous familial hyperlipidemia. Please enable it to take advantage of the complete set of features! 2018 Oct;277:195-203. doi: 10.1016/j.atherosclerosis.2018.06.002. USA.gov. NIH Keywords: Data Synthesis: The findings from this review show that bempedoic acid is a safe and effective option for lowering LDL-C levels in patients requiring LDL-C lowering for primary or secondary prevention of cardiovascular events. This site needs JavaScript to work properly. Based on available data, bempedoic acid significantly lowers LDL-C and other atherogenic lipoprotein measures, and high-sensitivity C-reactive protein when added to background lipid-lowering therapy in patients with and without statin intolerance. Relevance to Patient Care and Clinical Practice: Statin therapy remains the mainstay of treatment for both primary and secondary prevention. Lessons from a lipid clinic. Herz. HHS  |  Curr Opin Lipidol.  |  2019 Feb;30(1):1-9. doi: 10.1097/MOL.0000000000000565. This site needs JavaScript to work properly. J Cardiovasc Pharmacol. NLM Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia. JAMA Cardiol. Furthermore, bempedoic acid is a prodrug that becomes activated by an enzyme expressed primarily in the liver, allowing it to avoid the potential myotoxicity associated with statin therapy. Drugs. Bempedoic acid: effects on lipoprotein metabolism and atherosclerosis. Objective: To review the pharmacology, pharmacokinetics, safety, and efficacy of bempedoic acid for low-density lipoprotein cholesterol (LDL-C) reduction.  |  Bempedoic Acid (Oral) Reviews Be the first to review Bempedoic Acid (Oral) and share your experience with other Everyday Health users. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE. NIH 2016 Dec;41(8):671-676. doi: 10.1007/s00059-016-4505-6. Role of Bempedoic Acid in Dyslipidemia Management. HHS Lloyd-Jones DM, Morris PB, Ballantyne CM, Birtcher KK, Daly DD Jr, DePalma SM, Minissian MB, Orringer CE, Smith SC Jr. J Am Coll Cardiol. Additional data regarding effect on long-term cardiovascular outcomes with bempedoic acid are currently being studied. USA.gov. Gencer B, Koskinas KC, Räber L, Karagiannis A, Nanchen D, Auer R, Carballo D, Carballo S, Klingenberg R, Heg D, Matter CM, Lüscher TF, Rodondi N, Mach F, Windecker S. J Am Heart Assoc. Drugs Context. 2020 Aug 24;9:2020-6-5. doi: 10.7573/dic.2020-6-5. Abstract. Eligibility for PCSK9 Inhibitors According to American College of Cardiology (ACC) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) Guidelines After Acute Coronary Syndromes. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/.  |  Please enable it to take advantage of the complete set of features! Get the latest public health information from CDC: https://www.coronavirus.gov. In early clinical trials, BA was well tolerated and … Banach M, Duell PB, Gotto AM Jr, Laufs U, Leiter LA, Mancini GBJ, Ray KK, Flaim J, Ye Z, Catapano AL. Data Sources: A PubMed search was conducted from January 2000 to June 15, 2020, using the keyword bempedoic acid for phase III clinical trials published in the English language. How effective are the ESC/EAS and 2013 ACC/AHA guidelines in treating dyslipidemia? Study Selection and Data Extraction: Articles related to the Food and Drug Administration (FDA) approval of bempedoic acid and other trials relating to the safety and efficacy of this drug were included. Get the latest research from NIH: https://www.nih.gov/coronavirus. Bempedoic acid (BA) is a novel lipid‐lowering drug. 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